产品名称 ARRY-520 from CAYMAN CHEMICAL COMPANY
产品货号 21883-1
产品价格 现货询价,电话:010-67529703
产品规格 1 mg
产品品牌 CAYMAN CHEMICAL COMPANY
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Product NameARRY-520
DescriptionA potent Eg5 inhibitor (IC50 = 6 nM); selective for Eg5 over a panel of 8 kinesins (IC50s = >100 µM) and a panel of 224 kinases at 10 µM; induces time-and dose-dependent cell death in HL-60, Jurkat, OCI-AML3, U937, and MOLM-13 leukemic cells; induces cell cycle arrest at the G2/M phase in a p53- and XIAP-independent manner in OCI-AML3 cells; inhibits blast colony formation of bone marrow samples derived from human AML patients; completely eliminates tumors in the RPMI-8226 multiple myeloma and HL-60 and MV4-11 AML mouse xenograft models at 20 mg/kg per day ,
Size1 mg
Concentrationn/a
Applicationsn/a
Other NamesFilanesib
Gene, Accession, CAS #CAS: 885060-09-3
Catalog #21883-1
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Order / More InfoARRY-520 from CAYMAN CHEMICAL COMPANY
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