| 产品详情 |
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| Product Name | DBeQ |
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| Description | Purity >98%. The ATPase p97 is an ubiquitin-selective chaperone known to play a critical role in the degradation of misfolded membrane and secretory proteins and has been linked to various cellular processes that require unfolding and disassembly of protein complexes. DBeQ is a selective, reversible, and ATP-competitive inhibitor of the ATPase p97 (Ki = 3.2 µM; IC50 = 1.5 µM). It does not exhibit activity when tested against a panel 170 protein kinases at concentrations as high as 15 µM. At 10 µM it blocks endoplasmic reticulum-associated degradation, impairing the autophagy pathway and promoting the activation of caspase-3 and -7 in cancer cells. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | N2 ,N4 -bis (phenylmethyl)-2,4-quinazolinediamine, JRF 12, N,N'-Dibenzylquinazoline-2,4-diamine |
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| Gene, Accession, CAS # | CAS: 177355-84-9 |
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| Catalog # | LS-H7375 |
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| Order / More Info | DBeQ from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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| 产品资料 |
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