| 产品详情 |
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| Product Name | Nat-20(S)-yne |
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| Description | Purity >95%. Smoothened (SMO) is a GPCR-like receptor which, with Patched, mediates hedgehog signaling to regulate gene expression through the Gli transcription factors. 20(S)-hydroxy Cholesterol (20(S)-OHC) is an oxysterol which binds SMO and activates hedgehog signaling (EC50 = 3 µM), and this activation is selective for the nat -20(S)-OHC enantiomer. Nat -20(S)-OHC synergizes with the SMO agonist SAG, suggesting an allosteric effect. Nat -20(S)-yne is a form of nat -20(S)-OHC with a terminal alkyne group, which can be used in linking reactions known as click chemistry. Click chemistry involves highly dependable and specific azide-alkyne bioconjugation reactions and can be used to capture or immobilize bioactive molecules. Thus, nat -20(S)-yne has been conjugated with magnetic beads to demonstrate that nat -20(S)-OHC directly binds SMO. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 26,27-dinorcholest-5-en-24-yne-3Beta,20-diol, Nat-20(S)-yne |
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| Gene, Accession, CAS # | CAS: 1397692-46-4 |
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| Catalog # | LS-H8919 |
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| Price | |
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| Order / More Info | Nat-20(S)-yne from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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