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| Product Name | UPF-1069 |
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| Description | Purity >98%. The poly(ADP-ribose) polymerases (PARPs) form a family of enzymes with roles in DNA repair and apoptosis, particularly in response to reactive oxygen and nitrogen species. UPF-1069 is a PARP inhibitor that demonstrates a modest preference for PARP2 over PARP1 (IC50 s = 0.3 and 8 µM, respectively). In rat models of post-ischemic brain damage, it has been shown to increase cell death in hippocampal slice cultures in a model characterized by loss of neurons through a caspase-dependent, apoptosis-like process but to be protective of cortical neurons in a model characterized by a necrosis-like process. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 5-(2-oxo-2-phenylethoxy)-1(2H)-isoquinolinone, GKT237841 |
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| Gene, Accession, CAS # | CAS: 1048371-03-4 |
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| Catalog # | LS-H10384 |
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| Order / More Info | UPF-1069 from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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