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| Product Name | JW55 |
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| Description | Purity >98% by HPLC. JW55 is a small molecule inhibitor of the Wnt/Beta-catenin signaling pathway that functions via inhibition of the PARP domain of tankyrase 1 and tankyrase 2 (TNKS1/2), regulators of the Beta-catenin destruction complex. Inhibition of TNKS1/2 poly(ADP-ribosyl)ation activity by JW55 leads to stabilization of AXIN2, a member of the Beta-catenin destruction complex, followed by increased degradation of Beta-catenin. In a dose-dependent manner, JW55 inhibits canonical Wnt signaling in colon carcinoma cells that contained mutations in either the APC (adenomatous polyposis coli) locus or in an allele of Beta-catenin. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | N-[4-[[[[Tetrahydro-4-(4-methoxyphenyl)-2H-pyran-4-yl]methyl]amino]carbonyl]phenyl]-2-furancarboxamide |
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| Gene, Accession, CAS # | CAS: 664993-53-7 |
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| Catalog # | LS-H3176 |
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| Order / More Info | JW55 from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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| 产品资料 |
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