| 产品详情 |
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| Product Name | JW 480 |
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| Description | Purity >98%. The transmembrane enzyme KIAA1363 (also known as AADACL1) controls the production of the monoalkylglycerol ether (MAGE) class of neutral ether lipids (NELs) in cancer cells. Hyperactivity of this 2-acetyl MAGE hydrolase is associated with tumor cell migration, invasion, survival, and growth. JW 480 acts as a potent, selective inhibitor of KIAA1361 (IC50 s = 20 nM in mouse brain membrane proteomes and 6-12 nM in human PC3 prostate cancer cell proteomes), showing little cross reactivity with hormone-sensitive lipase, acetylcholinesterase, or other serine hydrolases. JW 480 is active in vivo, reducing PC3 tumor xenograft growth in immune-deficient SCID mice at an oral dose of 80 mg/kg. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 2-isopropylphenyl(2-(naphthalen-2-yl)ethyl)carbamate |
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| Gene, Accession, CAS # | CAS: 1354359-53-7 |
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| Catalog # | LS-H8309 |
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| Price | |
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| Order / More Info | JW 480 from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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| 产品资料 |
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