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| Product Name | JW 55 |
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| Description | Purity >98%. JW 55 is an inhibitor of the PARP domain of tankyrases (TNKS) 1 and 2 (IC50 s = 1.9 and 0.83 µM, respectively). By inhibiting TNKS1/2, JW 55 stabilizes Axin2 and increases degradation of Beta-catenin, inhibiting the Beta-catenin signaling pathway (IC50 = 470 nM). It has been shown to decrease canonical Wnt signaling in SW480 and HCT15 colon carcinoma cell lines and to reduce proliferation of SW480 cells in vitro . |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | N-[4-[[[[tetrahydro-4-(4-methoxyphenyl)-2H-pyran-4-yl]methyl]amino]carbonyl]phenyl]-2-furancarboxamide, Tankyrase 1/2 Inhibitor IV |
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| Gene, Accession, CAS # | CAS: 664993-53-7 |
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| Catalog # | LS-H8310 |
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| Price | |
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| Order / More Info | JW 55 from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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