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| Product Name | Recombinant Human Heterogeneous nuclear ribonucleoprotein K (HNRNPK), partial |
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| Description | Purity > 90% as determined by SDS-PAGE. MW: 77.8kDa. Partial: 3-459aa. N-terminal GST-tagged. Homo sapiens (Human). One of the major pre-mRNA-binding proteins. Binds tenaciously to poly (C) sequences. Likely to play a role in the nuclear metabolism of hnRNAs, particularly for pre-mRNAs that contain cytidine-rich sequences. Can also bind poly (C) single-stranded DNA. Plays an important role in p53/TP53 response to DNA damage, acting at the level of both transcription activation and repression. When sumoylated, acts as a transcriptional coactivator of p53/TP53, playing a role in p21/CDKN1A and 14-3-3 sigma/SFN induction. As far as transcription repression is concerned, acts by interacting with long intergenic RNA p21 (lincRNA-p21), a non-coding RNA induced by p53/TP53. This interaction is necessary for the induction of apoptosis, but not cell cycle arrest.3 Publications |
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| Size | 100ug |
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| Concentration | n/a |
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| Applications | RUO |
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| Other Names | Transformation up-regulated nuclear protein; TUNP |
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| Gene, Accession, CAS # | HNRNPK, UniProt: P61978 |
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| Catalog # | RPC25847 |
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| Price | |
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| Order / More Info | Recombinant Human Heterogeneous nuclear ribonucleoprotein K (HNRNPK), partial from BIOMATIK |
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| Product Specific References | n/a |
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