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| Product Name | Recombinant Mouse Interferon regulatory factor 3 (Irf3) |
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| Description | Purity > 90% as determined by SDS-PAGE. MW: 50.9kDa. Full Length: 1-419aa. N-terminal 10xHis-tagged and C-terminal Myc-tagged. Mus musculus (Mouse). Key transcriptional regulator of type I interferon (IFN)-dependent immune responses which plays a critical role in the innate immune response against DNA and RNA viruses. Regulates the transcription of type I IFN genes (IFN-alpha and IFN-beta) and IFN-stimulated genes (ISG) by binding to an interferon-stimulated response element (ISRE) in their promoters. Acts as a more potent activator of the IFN-beta (IFNB) gene than the IFN-alpha (IFNA) gene and plays a critical role in both the early and late phases of the IFNA/B gene induction. Found in an inactive form in the cytoplasm of uninfected cells and following viral infection, double-stranded RNA (dsRNA), or toll-like receptor (TLR) signaling, is phosphorylated by IKBKE and TBK1 kinases. This induces a conformational change, leading to its dimerization and nuclear localization and association with CREB binding protein (CREBBP) to form dsRNA-activated factor 1 (DRAF1), a complex which activates the transcription of the type I IFN and ISG genes. Can activate distinct gene expression programs in macrophages and can induce significant apoptosis in primary macrophages. |
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| Size | 100ug |
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| Concentration | n/a |
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| Applications | RUO |
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| Other Names | Short name:IRF-3 |
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| Gene, Accession, CAS # | Irf3, UniProt: P70671 |
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| Catalog # | RPC24758 |
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| Order / More Info | Recombinant Mouse Interferon regulatory factor 3 (Irf3) from BIOMATIK |
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| Product Specific References | n/a |
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