| 产品详情 |
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| Product Name | ZK118182 isopropyl ester |
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| Description | Purity >98%. Elevated intraocular pressure (IOP) is an important risk factor in developing glaucoma. Certain prostaglandins (PGs) such as PGF2Alpha and PGD2, have been shown to reduce IOP. ZK118182 is a PG analog that has potent DP-agonist activity (EC50 = 16.5 nM) and a high nanomolar affinity for the DP receptor (Ki = 74 nM). ZK118182 isopropyl ester is a prodrug formulation of ZK118182 designed to enhance corneal absorption. At 0.03 µg, ZK118182 isopropyl ester has been shown to lower monkey and rabbit IOP 46% and 20%, respectively, two hours after dosing, demonstrating a much more potent effect compared to the free acid. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | [[4-[5R-chloro-2Z-[3R-cyclohexyl-3S-hydroxy-1R-propenyl]-3S-hydroxycyclopentyl]-2R-butenyl]oxy]-acetic acid, isopropyl ester |
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| Gene, Accession, CAS # | CAS: 154927-31-8 |
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| Catalog # | LS-H10574 |
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| Price | |
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| Order / More Info | ZK118182 isopropyl ester from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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