| 产品详情 |
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| Product Name | Fenretinide |
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| Description | Purity >98%. Fenretinide is a synthetic derivative of retinoic acid and an inhibitor of dihydroceramide desaturase (IC50 = 2.32 µM). It promotes the generation of reactive oxygen species (ROS), the degradation of anti-apoptotic MCL-1, and the cleavage of pro-apoptotic PKCDelta. At 5-20 µM, fenretinide selectively activates retinoic acid receptor Gamma (RARGamma) and is reported to inhibit the growth of Caov-3, OVCAR-3, and SK-OV-3 ovarian cancer cells with IC50 values of 3.7, 6.9, and 8.2 µM, respectively. It also increases activity of serine palmitoyl transferase (SPT) by 1.75-fold and induces caspase-dependent apoptosis in BMEC cells (IC50 = 2.4 µM). Fenretinide prevents lipid-induced reductions in insulin-stimulated glucose uptake in isolated rat soleus muscle. In vivo, fenretinide (10 mg/ml in drinking water) reduces liver and soleus muscle neutral lipid content and inhibits high-fat diet-induced increases in dihydroceramide desaturase transcription. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | N-(4-hydroxyphenyl)-retinamide, 4-HPR, MK-4016, Ro 22-4667, 4-Hydroxy(phenyl)retinamide, Retinoic Acid p-hydroxyphenylamide |
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| Gene, Accession, CAS # | CAS: 65646-68-6 |
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| Catalog # | LS-H7772 |
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| Price | |
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| Order / More Info | Fenretinide from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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| 产品资料 |
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