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| Antigenic Specificity | RAD9 Homolog A (S. Pombe) (RAD9A) |
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| Clone | 3A3-A7-F8 |
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| Host Species | Mouse |
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| Reactive Species | human |
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| Isotype | IgG2b |
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| Format | affinity purified |
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| Size | 100 µL |
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| Concentration | n/a |
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| Applications | Western Blotting (WB),Immunoprecipitation (IP) |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | This gene product is highly similar to Schizosaccharomyces pombe rad9,a cell cycle checkpoint protein required for cell cycle arrest and DNA damage repair. This protein possesses 3' to 5' exonuclease activity,which may contribute to its role in sensing and repairing DNA damage. It forms a checkpoint protein complex with RAD1 and HUS1. This complex is recruited by checkpoint protein RAD17 to the sites of DNA damage,which is thought to be important for triggering the checkpoint-signaling cascade. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq,Aug 2011]Component of the 9-1-1 cell-cycle checkpoint response complex that plays a major role in DNA repair. The 9-1-1 complex is recruited to DNA lesion upon damage by the RAD17-replication factor C(RFC)clamp loader complex. Acts then as a sliding clamp platform on DNA for several proteins involved in long-patch base excision repair(LP-BER). The 9-1-1 complex stimulates DNA polymerase beta(POLB)activity by increasing its affinity for the 3'-OH end of the primer-template and stabilizes POLB to those sites where LP-BER proceeds,endonuclease FEN1 cleavage activity on substrates with double,nick,or gap flaps of distinct sequences and lengths,and DNA ligase I(LIG1)on long-patch base excision repair substrates. The 9-1-1 complex is necessary for the recruitment of C12orf32/RHINO to sites of double-stranded breaks(DSB)occurring during the S phase. RAD9A possesses 3'->5' double stranded DNA exonuclease activity. Its phosphorylation by PRKCD may be required for the formation of the 9-1-1 complex. Subunit structure: Component of the toroidal 9-1-1 (RAD9-RAD1-HUS1) complex,composed of RAD9A, RAD1 and HUS1. The 9-1-1 complex associates with LIG1,POLB,FEN1,RAD17,HDAC1,RPA1 and RPA2. The 9-1-1 complex associates with the RAD17-RFC complex. RAD9A interacts with BCL2L1,FEN1,PRKCD,RAD9B,HUS1,RAD1,ABL1,RPA1,ATAD5 and RPA2. Interacts with DNAJC7 and C12orf32/RHINO. Subcellular location: NucleusSequence similarities: Belongs to the rad9 family. |
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| Immunogen | Purified recombinant human RAD9A protein fragments expressed in E.coli |
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| Other Names | rad9a|MGC89062|Rad9|RAD9 |
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| Gene, Accession # | Gene ID: 5883 |
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| Catalog # | ABIN1558227 |
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| Price | |
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| Order / More Info | RAD9 Homolog A (S. Pombe) (RAD9A) Antibody from ANTIBODIES-ONLINE GmbH |
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| Product Specific References | n/a |
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