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| Product Name | EMD 1214063 |
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| Description | Purity >98%. MET is a proto-oncogene that encodes the hepatocyte growth factor receptor c-Met. It has normal roles in morphogenesis, migration, apoptosis, and angiogenesis. Dysregulation of c-Met occurs in many types of cancer. EMD 1214063 inhibits c-Met with an IC50 value of 3 nM, demonstrating at least 1,000-fold selectivity for c-Met over a panel of 242 additional kinases. It has been shown to inhibit c-Met phosphorylation and downstream signaling in various cancer cell lines (IC50 s = 6-9 nM) and, at 5-15 mg/kg, to regress tumors in mouse xenograft models. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 3-[1,6-dihydro-1-[[3-[5-[(1-methyl-4-piperidinyl)methoxy]-2-pyrimidinyl]phenyl]methyl]-6-oxo-3-pyridazinyl]-benzonitrile, MSC2156119, Tepotinib |
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| Gene, Accession, CAS # | CAS: 1100598-32-0 |
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| Catalog # | LS-H7652 |
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| Order / More Info | EMD 1214063 from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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