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| Product Name | Netrin-1, Recombinant, Human, Fc Chimera (NTN1, NTN1L, Netrin 1) |
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| Description | Purity ~95% (SDS-PAGE). Human Netrin-1 (netr: Sanskrit for ``one who guides'') is a 75kD glycoprotein that is closely related to the laminin y domain and functions as a chemoattractive or chemorepulsive guidance cue in the central nervous system (CNS) during development (1-2). The protein is synthesized as a 604aa precursor that contains a 24aa signal sequence and a 580aa mature chain. Residues 46-283 constitute a laminin N-terminal domain (domain VI), while 285-453 make up three laminin-type epidermal growth factor-like domains. There is a final domain that runs from aa487-601 that qualifies as a Netrin- 1 like domain. It is also known as domain C in the context of C. elegans. There are four potential sites for N-linked glycosylation. Human Netrin-1 is 99% aa identical to mouse and rat Netrin-1. Netrin-1 is expressed in adult and embryonic tissues. In the adult, the protein is expressed in Schwann cells, oligodendrocytes and multiple neurons. In embryonic tissues, Netrin-1 is found in s |
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| Size | 25ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | n/a |
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| Gene, Accession, CAS # | Accession: O95631 |
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| Catalog # | N1193-16F |
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| Order / More Info | Netrin-1, Recombinant, Human, Fc Chimera (NTN1, NTN1L, Netrin 1) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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