产品名称 Fc Fragment of IgG, Low Affinity IIIa, Receptor (CD16a) (FCGR3A) (AA 17-208) protein (His tag) from ANTIBODIES-ONLINE GmbH
产品货号 ABIN1096633
产品价格 现货询价,电话:010-67529703
产品规格 50 µg
产品品牌 ANTIBODIES-ONLINE GmbH
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Product NameFc Fragment of IgG, Low Affinity IIIa, Receptor (CD16a) (FCGR3A) (AA 17-208) protein (His tag)
DescriptionReceptors for the Fc region of immunoglobin G (FcgammaR) are divided into three classes and FcgammaRIII is a multifunctional, low/intermediate affinity receptor. In humans, FcgammaRIII is expressed as two distinct forms (FcgammaRIIIA and FcgammaRIIIB) that are encoded by two different but highly homologous genes in a cell type-specific manner. FcgammaRIIIB is a low-affinity, GPI-linked receptor expressed by neutrophils and eosinophils, whereas FcgammaRIIIA is an intermediate affinity polypeptide-anchored transmembrane glycoprotein expressed by a subset of T lymphocytes, natural killer (NK) cells, monocytes, and macrophages. The FcgammaRIIIA receptor is involved in phagocytosis, secretion of enzymes, inflammatory mediators, antibody-dependent cellular cytotoxicity (ADCC), mast cell degranulation, and clearance of immune complexes. FcgammaRIIIA has an immunoreceptor tyrosine-based activation motif (ITAM) in its cytoplasmic domain and delivers an activation signal in the immune responses. Aberrant expression or mutations in this gene is implicated in susceptibility to recurrent viral infections, systemic lupus erythematosus, and alloimmune neonatal neutropenia. In humans, it is a 50 -70 kD type I transmembrane activating receptor. The FcgammaRIIIA cDNA encodes 254 amino acid including a 16aa signal sequence, 191 amino acid ECD with two C2-type Ig-like domains, five potential N-glycosylation sites, a 22 amino acid transmembrane sequence and a 25 amino acid cytoplasmic domain.Alternative Names: Low Affinity Immunoglobulin Gamma Fc Region Receptor III-A, CD16a Antigen, Fc-Gamma RIII-Alpha, Fc-Gamma RIII, Fc-gamma RIIIa, FcRIII, FcRIIIa, FcR-10, IgG Fc Receptor III-2, CD16a, FCGR3A, CD16A, FCG3, FCGR3, IGFR3
Size50 µg
Concentrationn/a
Applicationsn/a
Other NamesCD16|CD16A|FCG3|FCGR3|FCGRIII|FCR-10|FCRIII|FCRIIIA|IGFR3
Gene, Accession, CAS #Gene ID: 2214
Catalog #ABIN1096633
Price
Order / More InfoFc Fragment of IgG, Low Affinity IIIa, Receptor (CD16a) (FCGR3A) (AA 17-208) protein (His tag) from ANTIBODIES-ONLINE GmbH
Product Specific Referencesn/a
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