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| Product Name | Recombinant Human Stromal cell-derived factor 1 protein (CXCL12) (Active) |
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| Description | Purity > 95% as determined by SDS-PAGE. MW: 17.7kDa. Full Length: 1-158aa. tag-Free. Homo sapiens (Human). Human Interleukin-36a (IL-36a) is a secreted cytokine that belongs to the Interleukin 1 cytokine family. IL-36a is expressed in the immune system and the fetal brain, but not in other tissues or multiple hematopoietic cell lines. IL-36a is the only IL-1 family member found to be expressed on T-cells. IL-36a and IL-1F8 are involved in the regulation of adipose tissue gene expression. Importantly, IL-36a inhibits PPAR? expression, which may lead to a reduction in adipocyte differentiation suggesting metabolic effects of this cytokine. IL-36a, along with IL-1F8 and IL-1F9, has been shown to act as an agonist by activating the pathway involving NF?B and MAPK in an IL-1Rrp2 dependent manner. This suggest that IL-36a may signal in a similar fashion to IL-1 and IL-18 in having a binding receptor which upon ligation, recruits a second receptor as a signaling component, forming an active heterodimeric receptor complex. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | RUO |
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| Other Names | Interleukin-36 Alpha; FIL1 Epsilon; Interleukin-1 Epsilon; IL-1 Epsilon; Interleukin-1 Family Member 6; IL-1F6; IL36A; FIL1E; IL1E; IL1F6 |
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| Gene, Accession, CAS # | IL36A, UniProt: Q9UHA7 |
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| Catalog # | RPC26888 |
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| Order / More Info | Recombinant Human Stromal cell-derived factor 1 protein (CXCL12) (Active) from BIOMATIK |
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| Product Specific References | n/a |
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