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| Product Name | Recombinant Human Stromal cell-derived factor 1 protein (CXCL12) (Active) |
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| Description | Purity > 96% as determined by SDSPAGE and HPLC. MW: 11.6kDa. Partial of Isoform Gamma: 21-119aa. tag-Free. Homo sapiens (Human). Chemoattractant active on T-lymphocytes, monocytes, but not neutrophils. Activates the C-X-C chemokine receptor CXCR4 to induce a rapid and transient rise in the level of intracellular calcium ions and chemotaxis. Also binds to atypical chemokine receptor ACKR3, which activates the beta-arrestin pathway and acts as a scavenger receptor for SDF-1. SDF-1-beta (3-72) and SDF-1-alpha (3-67) show a reduced chemotactic activity. Binding to cell surface proteoglycans seems to inhibit formation of SDF-1-alpha (3-67) and thus to preserve activity on local sites. Acts as a positive regulator of monocyte migration and a negative regulator of monocyte adhesion via the LYN kinase. Stimulates migration of monocytes and T-lymphocytes through its receptors, CXCR4 and ACKR3, and decreases monocyte adherence to surfaces coated with ICAM-1, a ligand for beta-2 integrins. SDF1A/CXCR4 signaling axis inhibits beta-2 integrin LFA-1 mediated adhesion of monocytes to ICAM-1 through LYN kinase. Inhibits CXCR4-mediated infection by T-cell line-adapted HIV-1. Plays a protective role after myocardial infarction. Induces down-regulation and internalization of ACKR3 expressed in various cells. Has several critical functions during embryonic development; required for B-cell lymphopoiesis, myelopoiesis in bone marrow and heart ventricular septum formation. {ECO:0000269|PubMed:11069075, ECO:0000269|PubMed:11859124, ECO:0000269|PubMed:16107333, ECO:0000269|PubMed:18802065, ECO:0000269|PubMed:19255243, ECO:0000269|PubMed:8752281}. |
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| Size | 100ug |
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| Concentration | n/a |
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| Applications | RUO |
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| Other Names | SDF-1, C-X-C motif chemokine 12, Intercrine reduced in hepatomas, IRH, hIRH |
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| Gene, Accession, CAS # | CXCL12,SDF1,SDF1A,SDF1B, UniProt: P48061 |
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| Catalog # | RPC26578 |
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| Order / More Info | Recombinant Human Stromal cell-derived factor 1 protein (CXCL12) (Active) from BIOMATIK |
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| Product Specific References | n/a |
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