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| Product Name | Noggin (NOG) (Active) protein |
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| Description | Noggin belongs to a group of diffusible proteins which bind to ligands of the TGF-beta family and regulate their activity by inhibiting their access to signaling receptors. Noggin was originally identified as a BMP-4 antagonist whose action is critical for proper formation of the head and other dorsal structures. Consequently, Noggin has been shown to modulate the activities of other BMPs including BMP-2,-7,-13, and -14. Targeted deletion of Noggin in mice results in prenatal death and recessive phenotype displaying a severely malformed skeletal system. Conversely, transgenic mice over-expressing Noggin in mature osteoblasts display impaired osteoblastic differentiation, reduced bone formation, and severe osteoporosis. Synonym: NOGGIN, Human. Formulation: Lyophilized from a 0.2µm filtered concentrated solution in 30% acetonitrile, 0.1% TFA. |
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| Size | 20 µg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | noggin|SYM1|SYNS1|nog-A|nog1|noggin-1 |
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| Gene, Accession, CAS # | Gene ID: 9241 |
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| Catalog # | ABIN988177 |
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| Order / More Info | Noggin (NOG) (Active) protein from ANTIBODIES-ONLINE GmbH |
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| Product Specific References | n/a |
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