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| Product Name | Recombinant Mouse Interleukin-36 gamma protein (Il36g) (Active) |
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| Description | Purity > 98% as determined by SDS-PAGE and HPLC. MW: 17.3kDa. Full Length of Mature Protein: 13-164aa. tag-Free. Mus musculus (Mouse). Function as an agonist of NF-kappa B activation through the orphan IL-1-receptor-related protein 2/IL1RL2. Part of the IL-36 signaling system that is thought to be present in epithelial barriers and to take part in local inflammatory response; similar to the IL-1 system with which it shares the coreceptor IL1RAP (By similarity). Seems to be involved in skin inflammatory response by acting on keratinocytes, dendritic cells and indirectly on T cells to drive tissue infiltration, cell maturation and cell proliferation. May play a role in proinflammatory responses during particular neutrophilic airway inflammation. May be involved in the innate immune response to fungal pathogens. Induces the production of proinflammatory cytokines in bone marrow-derived dendritic cells (BMDCs), including IL-12, Il-1 beta, IL-6, TNF-alpha and IL-23. Involved in dendritic cell maturation by stimulating the surface expression of CD80, CD86 and MHC class II. Induces the production of IFN-gamma, IL-4 and IL-17 by cultured CD4 (+) T cells and splenocytes. {ECO:0000250|UniProtKB:Q9NZH8, ECO:0000269|PubMed:21860022, ECO:0000269|PubMed:21965679}. |
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| Size | 100ug |
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| Concentration | n/a |
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| Applications | RUO |
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| Other Names | Interleukin-1 family member 9, |
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| Gene, Accession, CAS # | Il36g,Il1f9, UniProt: Q8R460 |
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| Catalog # | RPC26787 |
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| Order / More Info | Recombinant Mouse Interleukin-36 gamma protein (Il36g) (Active) from BIOMATIK |
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| Product Specific References | n/a |
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