| 产品详情 |
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| Antigenic Specificity | B-Raf (Ser-446) |
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| Clone | polyclonal |
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| Host Species | Rabbit |
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| Reactive Species | human, rat, mouse |
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| Isotype | n/a |
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| Format | affinity purified |
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| Size | 0.1 mL |
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| Concentration | n/a |
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| Applications | ELISA, Western Blot |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | B-Raf (Ser-446), phospho-specific [Conserved Site: C-Raf (Ser-338)/A-Raf (Ser-299)]. This antibody was cross-adsorbed to phospho-B-Raf (Ser-579) peptide before affinity purification using phospho-B-Raf (Ser-446) peptide. The purified antibody detects a strong band at 95 kDa* and a weaker band at 105 kDa in western blots of human Jurkat or A431 cells treated with Calyculin A. The antibody also detects other phosphorylated proteins at 150 and 200 kDa in calyculin A treated cells. |
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| Immunogen | Phospho-B-Raf (Ser-446) synthetic peptide (coupled to KLH) corresponds to amino acids surrounding serine 446 in human B-Raf. This sequence is conserved in B-Rafs from many species, and has high homology to C-Raf (Ser-338) and A-Raf (Ser-299). |
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| Other Names | serine/threonine-protein kinase B-raf; Serine/threonine-protein kinase B-raf; serine/threonine-protein kinase B-raf; p94; OTTHUMP00000212184; 94 kDa B-raf protein; proto-oncogene B-Raf; murine sarcoma viral (v-raf) oncogene homolog B1; B-Raf proto-oncogene serine/threonine-protein kinase (p94); v-raf murine sarcoma viral oncogene homolog B1; Proto-oncogene B-Raf; p94; v-Raf murine sarcoma viral oncogene homolog B1, BRAF; BRAF; NS7; BRAF1; RAFB1; B-RAF1; FLJ95109; MGC126806; MGC138284; BRAF1; RAF |
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| Gene, Accession # | Gene ID: 673, NCBI: NP_004324.2, UniProt: P15056 |
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| Catalog # | MBS472012 |
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| Price | |
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| Order / More Info | B-Raf (Ser-446) Antibody from MYBIOSOURCE INC. |
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| Product Specific References | • Mason, C.S. et al. (1999) EMBOJ 18(8):2137. • Wilhelm, S.M. et al. (2004) Cancer Res 64:7099. • Karbowniczek, M. et al. (2006) J Biol Chem 281(35):25447. • Brummer, T. et al. (2006) Oncogene 25(47):6262. |
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