| 产品详情 |
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| Product Name | Tumor Necrosis Factor (Ligand) Superfamily, Member 13b (TNFSF13B) protein |
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| Description | Human B Cell Activating Factor B-cell activating factor (BlyS), also known as BAFF, TALL-1, TNAK, and zTNF4, is a TNF ligand superfamily member and has been designated TNFSF13B. Produced by macrophages, dendritic cells, and T lymphocytes, BAFF promotes the survival of B cells and is essential for B cell maturation. BAFF binds to three TNF receptor superfamily members: B-cell maturation antigen (BCMA/TNFRSF17), transmembrane activator and calcium-modulator and cyclophilin ligand interactor (TACI/TNFRSF13B) andBAFF receptor (BAFF R/BR3/TNFRSF 13C). These receptors are type III transmembrane proteins that lack a signal peptide. Whereas TACI and BCMA bind BAFF and another TNF superfamily ligand, APRIL(a proliferation-inducing ligand), BAFF R selectively binds BAFF. The BAFF R extracellular domain lacks the TNF receptor canonical cysteine-rich domain (CRD) and contains only a partial CRD with four cysteine residues. Human and mouse BAFF R share 56% aa sequence identity. BAFF R is highly expressed in spleen, lymph node and resting B cells. It is also expressed at lower levels in activated B cell, in resting CD4+ T cells, in thymus and peripheral blood leukocytes. |
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| Size | 1 mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | RGD1561519|TNFSF13B|BAFF|BLYS|CD257|DTL|TALL-1|TALL1|THANK|TNFSF20|ZTNF4|BLyS|D8Ertd387e|zTNF4 |
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| Gene, Accession, CAS # | Gene ID: 10673 |
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| Catalog # | ABIN1540397 |
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| Order / More Info | Tumor Necrosis Factor (Ligand) Superfamily, Member 13b (TNFSF13B) protein from ANTIBODIES-ONLINE GmbH |
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| Product Specific References | n/a |
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