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| Product Name | MIB1, Recombinant, Human, aa5-332, His-Tag (E3 Ubiquitin-Protein Ligase MIB1) |
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| Description | Purity ~90% (SDS-PAGE). E3 ubiquitin-protein ligase that mediates ubiquitination of Delta receptors, which act as ligands of Notch proteins. Positively regulates the Delta-mediated Notch signaling by ubiquitinating the intracellular domain of Delta, leading to endocytosis of Delta receptors. Probably mediates ubiquitination and subsequent proteasomal degradation of DAPK1, thereby antagonizing anti-apoptotic effects of DAPK1 to promote TNF-induced apoptosis. Involved in ubiquitination of centriolar satellite CEP131, CEP290 and PCM1 proteins and hence inhibits primary cilium formation in proliferating cells. Mediates 'Lys-63'-linked polyubiquitination of TBK1, which probably participates in kinase activation. Source: Recombinant protein corresponding to aa5-332 from human MIB1, fused to His-Tag at N-terminal, expressed in E. coli. Molecular Weight: ~40.1kD AA |
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| Size | 10ug, 50ug, 100ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | DAPK-interacting protein 1, DIP-1, Mind bomb homolog 1, Zinc finger ZZ type with ankyrin repeat domain protein 2 |
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| Gene, Accession, CAS # | SwissProt: Q86YT6 |
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| Catalog # | 374207 |
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| Order / More Info | MIB1, Recombinant, Human, aa5-332, His-Tag (E3 Ubiquitin-Protein Ligase MIB1) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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