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| Antigenic Specificity | Discoidin Domain Receptor tyrosine Kinase 1 (DDR1) (aa 602-681) |
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| Clone | 2G4E12 |
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| Host Species | Mouse |
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| Reactive Species | human |
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| Isotype | IgG1 |
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| Format | ascites |
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| Size | 100 µL |
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| Concentration | n/a |
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| Applications | ELISA,Western Blotting (WB) |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | DDR1: discoidin domain receptor tyrosine kinase 1. Receptor tyrosine kinases (RTKs) play a key role in the communication of cells with their microenvironment. These molecules are involved in the regulation of cell growth, differentiation and metabolism. The protein encoded by this gene is a RTK that is widely expressed in normal and transformed epithelial cells and is activated by various types of collagen. This protein belongs to a subfamily of tyrosine kinase receptors with a homology region to the Dictyostelium discoideum protein discoidin I in their extracellular domain. Its autophosphorylation is achieved by all collagens so far tested (type I to type VI). In situ studies and Northern-blot analysis showed that expression of this encoded protein is restricted to epithelial cells, particularly in the kidney, lung, gastrointestinal tract, and brain. In addition, this protein is significantly over-expressed in several human tumors from breast, ovarian, esophageal, and pediatric brain. This gene is located on chromosome 6p21.3 in proximity to several HLA class I genes. Alternative splicing of this gene results in multiple transcript variants. |
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| Immunogen | Purified recombinant fragment of DDR1 (AA 602-681) expressed in E. coli. |
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| Other Names | CG11573|CG13984|CG13985|CG33531|CG9488|CG9490|CT33540|DDR|Dmel\\CG33531|Dmel_CG13984|6030432F18|AI323681|CD167a|Cak|Nep|PTK3A|CAK|CD167|EDDR1|HGK2|MCK10|NEP|NTRK4|PTK3|RTK6|TRKE|Drd1|PTK3D |
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| Gene, Accession # | Gene ID: 780 |
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| Catalog # | ABIN969082 |
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| Price | |
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| Order / More Info | Discoidin Domain Receptor tyrosine Kinase 1 (DDR1) (aa 602-681) Antibody from ANTIBODIES-ONLINE GmbH |
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| Product Specific References | PubMed: 10783152, 11133186, 12477932 |
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