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| Product Name | Platelet Derived Growth Factor BB (PDGFBB) (AA 74-182) (Active) protein |
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| Description | Platelet-Derived Growth Factor-BB (PDGF-BB) is one of five dimers (PDGF-AA, AB, BB, CC, and DD) formed by 4 different PDGF subunits. In vivo, PDGF-BB is mainly produced in heart and placenta, and predominantly expressed by osteoblasts, fibroblasts, smooth muscle cells, and glial cells. An inactive precursor of PDGF-BB is produced in the endoplasmic reticulum and then activated by a proprotein convertase after secretion. PDGF-BB functions in a paracrine manner and promotes organogenesis, human skeletal development, and wound healing. PDGF-BB also promotes angiogenesis, particularly in the presence of Fibroblast Growth Factor basic. Therefore, PDGF-BB and its related pathways are potential pharmacological targets.Recombinant rat Platelet-Derived Growth Factor-BB (rrPDGF-BB) produced in E. coli is a disulfide-linked homodimer containing two non-glycosylated polypeptide chains of 110 amino acids each. A fully biologically active molecule, rrPDGF-BB has a molecular mass of 24.6 kDa analyzed by non-reducing SDS-PAGE. Synonyms: Platelet-Derived Growth Factor-BB, Glioma-derived growth factor (GDGF), Osteosarcoma-derived Growth Factor (ODGF) |
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| Size | 1 mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | PDGF-2|PDGF2|SIS|SSV|c-sis |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | ABIN2018323 |
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| Order / More Info | Platelet Derived Growth Factor BB (PDGFBB) (AA 74-182) (Active) protein from ANTIBODIES-ONLINE GmbH |
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| Product Specific References | n/a |
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