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| Antigenic Specificity | Cas-Br-M (Murine) Ecotropic Retroviral Transforming Sequence (CBL) (aa 863-877), (C-Term) |
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| Clone | polyclonal |
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| Host Species | Rabbit |
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| Reactive Species | human, rat |
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| Isotype | n/a |
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| Format | immunogen affinity purified |
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| Size | 100 µg |
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| Concentration | n/a |
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| Applications | Western Blotting (WB) |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | CBL(Cbl proto-oncogene) is also known as C-CBL, RNF55, CBL2 and E3 ubiquitin protein ligase. Wei et al.(1990) mapped the CBL gene to chromosome 11q23.3-qter by molecular characterization of the breakpoints in 2 somatic cell hybrids. The encoded protein is one of the enzymes required for targeting substrates for degradation by the proteasome. This protein mediates the transfer of ubiquitin from ubiquitin conjugating enzymes(E2) to specific substrates. This protein also contains an N-terminal phosphotyrosine binding domain that allows it to interact with numerous tyrosine-phosphorylated substrates and target them for proteasome degradation. As such it functions as a negative regulator of many signal transduction pathways. This gene has been found to be mutated or translocated in many cancers including acute myeloid leukaemia. Mutations in this gene are also the cause of Noonan syndrome-like disorder. |
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| Immunogen | A synthetic peptide corresponding to a sequence at the C-terminus of human CBL(863-877aa NLMSQGYSYQDIQKA), identical to the related rat and mouse sequences. |
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| Other Names | 4732447J05Rik|Cbl-2|c-Cbl|cbl|C-CBL|CBL2|FRA11B|NSLL|RNF55|c-cbl-like|RGD1561386 |
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| Gene, Accession # | Gene ID: 867,500985 |
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| Catalog # | ABIN1673282 |
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| Price | |
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| Order / More Info | Cas-Br-M (Murine) Ecotropic Retroviral Transforming Sequence (CBL) (aa 863-877), (C-Term) Antibody from ANTIBODIES-ONLINE GmbH |
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| Product Specific References | PubMed: 10514377, 20619386, 2331673 |
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