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| Product Name | Signal Transducing Adaptor Molecule (SH3 Domain and ITAM Motif) 1 (STAM) protein |
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| Description | Signal Transducing Adaptor Molecule-1 (STAM-1) is a member the STAM family of adaptor molecules. This ubiquitously expressed protein is 540 amino acids (aa) in length with a predicted molecular weight of 59. 18 kDa. Human STAM-1 shares 91% and 92% aa sequence identity with the rat and mouse orthologs, respectively. It contains multiple domains including a VHS domain (aa 16-143) and a ubiquitin-interacting motif (aa 171-190), both of which bind ubiquitinated proteins, a SH3 domain (aa 210-269) that associates with the zinc metalloprotease STAMBP and an ITAM domain (aa 370-387), which contains a Hrs-binding site and interacts with Janus kinases (Jaks). STAM-1 is involved in downstream signaling stimulated by cytokines and growth factors. It is tyrosine phosphorylated by Jaks in response to a variety of cytokines including IL-2, IL-3, IL-4, IL-7, GM-CSF, EGF and PDGF, and has been shown to induce DNA synthesis and MYC expression. Additionally, STAM-1 has been shown to regulate CXCR4 signaling and appears to be important for T cell development and survival. Besides its role in signal transduction, STAM-1 may also be important for the regulation of endocytic membrane trafficking. It associates with Hrs to form the ESCRT-0 complex, which binds to ubiquitinated membrane proteins on early endosomes and directs them to the ESCRT-1 complex for lysosomal degradation. STAM-1 has also been shown to interact with coat protein II complexes and function in trafficking vesicles from the endoplasmic reticulum to the golgi apparatus. |
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| Size | 50 µg |
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| Concentration | n/a |
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| Applications | SDS-PAGE (SDS) |
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| Other Names | STAM-1|STAM1|wu:fv75b10|zgc:55725|RGD1564499 |
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| Gene, Accession, CAS # | Gene ID: 8027 |
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| Catalog # | ABIN2745831 |
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| Order / More Info | Signal Transducing Adaptor Molecule (SH3 Domain and ITAM Motif) 1 (STAM) protein from ANTIBODIES-ONLINE GmbH |
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| Product Specific References | n/a |
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