产品名称 Desmoglein 2 (DSG2) Antibody from ANTIBODIES-ONLINE GmbH
产品货号 ABIN2191994
产品价格 现货询价,电话:010-67529703
产品规格 100 µg
产品品牌 ANTIBODIES-ONLINE GmbH
产品概述
产品详情
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Antigenic SpecificityDesmoglein 2 (DSG2)
Clone6D8
Host SpeciesMouse
Reactive Specieshuman
IsotypeIgG1
Formatunconjugated
Size100 µg
Concentrationn/a
ApplicationsWestern Blotting (WB),Immunohistochemistry (Frozen Sections) (IHC (fro))
Reviews / RatingsIf you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY.
DescriptionThe monoclonal antibody 6D8 recognizes the extracellular domain of human desmoglein-2. Desmogleins and desmocollins are members of the cadherin family of transmembrane proteins that together make up the core of the desmosome, a structure that provides transmembrane strength to tissues undergoing mechanical stress. The desmosomal cadherins, desmogleins and desmocollins, mediate calcium-dependent cell-cell adhesion by forming homotypic and heterotypic interactions with one another. The multiprotein desmosomal complex also includes the cytoplasmic desmosomal plaque proteins plakoglobin, phakophilins, and desmoplakin, which bind to the intracellular domain of the desmogleins and function to anchor the keratin intermediate filament network to site of cell-cell contacts. In human, four desmogleins have been identified (Dsg1-4). Desmogleins are synthesized with a signal peptide that directs them to the endoplasmic reticulum and a proregion that is removed during protein processing. The mature protein includes four highly conserved extracellular domains (EC 1-4) and a fifth membrane proximal, more variable EC domain that is referred to as the
Immunogenn/a
Other NamesDSG2|dsc|dsga|si:dkeyp-51f12.6|wu:fj23f02|ARVC10|ARVD10|CDHF5|CMD1BB|HDGC|AA408168|D18Ertd293e
Gene, Accession #Gene ID: 1829
Catalog #ABIN2191994
Price
Order / More InfoDesmoglein 2 (DSG2) Antibody from ANTIBODIES-ONLINE GmbH
Product Specific ReferencesPubMed: 8743961, 9049256, 12850306, 11991815
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