产品名称 Discs, Large Homolog 3 (Drosophila) (DLG3) (aa 1-120) Antibody from ANTIBODIES-ONLINE GmbH
产品货号 ABIN2482568
产品价格 现货询价,电话:010-67529703
产品规格 100 µg
产品品牌 ANTIBODIES-ONLINE GmbH
产品概述
产品详情
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Antigenic SpecificityDiscs, Large Homolog 3 (Drosophila) (DLG3) (aa 1-120)
CloneS19-2
Host SpeciesMouse
Reactive Specieshuman, mouse, rat
Isotypen/a
Formatalkaline phosphatase (AP) conjugate
Size100 µg
Concentrationn/a
ApplicationsImmunohistochemistry (IHC),Immunoprecipitation (IP),Western Blotting (WB)
Reviews / RatingsIf you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY.
DescriptionSynapse-associated protein 102 belongs to the membrane-associated guanylate kinase protein family and is a homolog of the Drosophila dis large tumor suppressor protein. SAP102 has extensive sequence homology to the PSD 95 family of proteins that facilitate ion channel clustering at synaptic terminal. SAP102 consists of three 90 amino acids PDZ domains at its amino terminus, a Src homology 3 domain and a guanylate kinase domain. All three PDZ domains of SAP102 participate in binding to the NMDA reception, interacting specifically with the carboxy-terminal domain of the N-methyl-D-aspartate receptor 2B (NR2B). The interaction may facilitate AMPA receptor withdrawal from the postsynaptic membrane by inhibiting the ERK/MAPK pathway. SAP102 also interacts with synaptic ras-GTPase activating protein synGAP through its PDZ domains. In general, the SAP102 protein is more highly expressed in non-proliferating cells than in proliferating cells, indicating a role in the negative regulation of cell growth.
ImmunogenFusion protein amino acids 1-120 of rat SAP102
Other NamesDlgh3|MRX|MRX90|NEDLG|SAP102|XLMR|mKIAA1232|fa66c08|fa66e02|fd02c12|fu95c12|im:7138640|si:ch211-276g21.1|wu:fa66c08|wu:fa66e02|wu:fd02c12|wu:fu95c12|MPP3
Gene, Accession #Gene ID: 1741,53310,58948
Catalog #ABIN2482568
Price
Order / More InfoDiscs, Large Homolog 3 (Drosophila) (DLG3) (aa 1-120) Antibody from ANTIBODIES-ONLINE GmbH
Product Specific ReferencesPubMed: 8780649
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