产品名称 Checkpoint Kinase 2 (CHEK2) (aa 481-531) Antibody from ANTIBODIES-ONLINE GmbH
产品货号 ABIN1724714
产品价格 现货询价,电话:010-67529703
产品规格 100 µL
产品品牌 ANTIBODIES-ONLINE GmbH
产品概述
产品详情
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Antigenic SpecificityCheckpoint Kinase 2 (CHEK2) (aa 481-531)
Clone1C12B8
Host SpeciesMouse
Reactive Specieshuman
IsotypeIgG2b
Formatunconjugated
Size100 µL
Concentrationn/a
ApplicationsELISA,Western Blotting (WB),Immunohistochemistry (IHC),Immunocytochemistry (ICC)
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DescriptionCHK2: CHK2 checkpoint homolog (S. pombe). In response to DNA damage and replication blocks, cell cycle progression is halted through the control of critical cell cycle regulators. The protein encoded by this gene is a cell cycle checkpoint regulator and putative tumor suppressor. It contains a forkhead-associated protein interaction domain essential for activation in response to DNA damage and is rapidly phosphorylated in response to replication blocks and DNA damage. When activated, the encoded protein is known to inhibit CDC25C phosphatase, preventing entry into mitosis, and has been shown to stabilize the tumor suppressor protein p53, leading to cell cycle arrest in G1. In addition, this protein interacts with and phosphorylates BRCA1, allowing BRCA1 to restore survival after DNA damage. Mutations in this gene have been linked with Li-Fraumeni syndrome, a highly penetrant familial cancer phenotype usually associated with inherited mutations in TP53. Also, mutations in this gene are thought to confer a predisposition to sarcomas, breast cancer, and brain tumors. This nuclear protein is a member of the CDS1 subfamily of serine/threonine protein kinases. Three transcript variants encoding different isoforms have been found for this gene.
ImmunogenPurified recombinant fragment of human CHK2 (aa481-531) expressed in E. Coli.
Other NamesCHK-2|CDS1|CHK2|HuCds1|LFS2|PP1425|RAD53|hCds1|Cds1|HUCDS1|Rad53|Chk2|fa66f08|wu:fa66f08|zgc:55865
Gene, Accession #Gene ID: 11200
Catalog #ABIN1724714
Price
Order / More InfoCheckpoint Kinase 2 (CHEK2) (aa 481-531) Antibody from ANTIBODIES-ONLINE GmbH
Product Specific ReferencesPubMed: 18004398, 17721994, 18281249
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