| 产品详情 |
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| Antigenic Specificity | Checkpoint Kinase 2 (CHEK2) |
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| Clone | polyclonal |
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| Host Species | Rabbit |
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| Reactive Species | mouse, rat, human |
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| Isotype | n/a |
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| Format | affinity purified |
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| Size | 50 µg |
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| Concentration | n/a |
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| Applications | Western Blotting (WB),Immunohistochemistry (IHC) |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | Chk2 is the mammalian orthologue of the budding yeast Rad53 and fission yeast Cds1 checkpoint kinases . The amino-terminal domain of Chk2 contains a series of seven serine or threonine residues (Ser19, Thr26, Ser28, Ser33, Ser35, Ser50, and Thr68) each followed by glutamine (SQ or TQ motif). These are known to be preferred sites for phosphorylation by ATM/ATR kinases . After DNA damage by ionizing radiation (IR), UV irradiation, or hydroxyurea treatment, Thr68 and other sites in this region become phosphorylated by ATM/ATR . The SQ/TQ cluster domain, therefore, seems to have a regulatory function. Phosphorylation at Thr68 is a prerequisite for the subsequent activation step, which is attributable to autophosphorylation of Chk2 at residues Thr383 and Thr387 in the activation loop of the kinase domain . Synonyms: CDS1, CHK2, HuCds1, LFS2, PP1425, RAD53, |
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| Immunogen | Recombinant protein of human CHEK2 |
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| Other Names | CHK-2|CDS1|CHK2|HuCds1|LFS2|PP1425|RAD53|hCds1|Cds1|HUCDS1|Rad53|Chk2|fa66f08|wu:fa66f08|zgc:55865 |
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| Gene, Accession # | Gene ID: 11200,50883,114212 |
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| Catalog # | ABIN1683487 |
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| Price | |
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| Order / More Info | Checkpoint Kinase 2 (CHEK2) Antibody from ANTIBODIES-ONLINE GmbH |
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| Product Specific References | n/a |
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