产品名称 Checkpoint Kinase 2 (CHEK2) Antibody from ANTIBODIES-ONLINE GmbH
产品货号 ABIN1683487
产品价格 现货询价,电话:010-67529703
产品规格 50 µg
产品品牌 ANTIBODIES-ONLINE GmbH
产品概述
产品详情
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Antigenic SpecificityCheckpoint Kinase 2 (CHEK2)
Clonepolyclonal
Host SpeciesRabbit
Reactive Speciesmouse, rat, human
Isotypen/a
Formataffinity purified
Size50 µg
Concentrationn/a
ApplicationsWestern Blotting (WB),Immunohistochemistry (IHC)
Reviews / RatingsIf you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY.
DescriptionChk2 is the mammalian orthologue of the budding yeast Rad53 and fission yeast Cds1 checkpoint kinases . The amino-terminal domain of Chk2 contains a series of seven serine or threonine residues (Ser19, Thr26, Ser28, Ser33, Ser35, Ser50, and Thr68) each followed by glutamine (SQ or TQ motif). These are known to be preferred sites for phosphorylation by ATM/ATR kinases . After DNA damage by ionizing radiation (IR), UV irradiation, or hydroxyurea treatment, Thr68 and other sites in this region become phosphorylated by ATM/ATR . The SQ/TQ cluster domain, therefore, seems to have a regulatory function. Phosphorylation at Thr68 is a prerequisite for the subsequent activation step, which is attributable to autophosphorylation of Chk2 at residues Thr383 and Thr387 in the activation loop of the kinase domain . Synonyms: CDS1, CHK2, HuCds1, LFS2, PP1425, RAD53,
ImmunogenRecombinant protein of human CHEK2
Other NamesCHK-2|CDS1|CHK2|HuCds1|LFS2|PP1425|RAD53|hCds1|Cds1|HUCDS1|Rad53|Chk2|fa66f08|wu:fa66f08|zgc:55865
Gene, Accession #Gene ID: 11200,50883,114212
Catalog #ABIN1683487
Price
Order / More InfoCheckpoint Kinase 2 (CHEK2) Antibody from ANTIBODIES-ONLINE GmbH
Product Specific Referencesn/a
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