产品名称 Checkpoint Kinase 2 (CHEK2) Antibody from ANTIBODIES-ONLINE GmbH
产品货号 ABIN180451
产品价格 现货询价,电话:010-67529703
产品规格 0.1 mg
产品品牌 ANTIBODIES-ONLINE GmbH
产品概述
产品详情
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Antigenic SpecificityCheckpoint Kinase 2 (CHEK2)
CloneDCS-293
Host SpeciesMouse
Reactive Specieshuman
IsotypeIgG1
FormatProtein G purified
Size0.1 mg
Concentrationn/a
ApplicationsImmunofluorescence (IF),Immunoprecipitation (IP),Western Blotting (WB)
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DescriptionCell cycle events are regulated by the sequential activation and deactivation of cyclin dependent kinases (Cdks) and by proteolysis of cyclins. Chk1 and Chk2 are involved in these processes as regulators of Cdks. Chk1 and Chk2 both functionas essential components in the G2 DNA damage checkpoint by phophorylating Cdc25C in response to DNA damage. Phosphorylation inhibits Cdc25C activity, thereby blocking mitosis. Cdc25A, Cdc25B and Cdc25C protein tyrosine phosphatases function as mitotic activators by dephosphorylating Cdc2 p34 on regulatory tyrosine residues. It has also been shown that Chk1 can phosphorylate Wee1 in vitro, providing evidence that the hyperphosphorylated form of Wee1, seen in cells delayed by Chk1 overexpression, is due to phosphorylation by Chk1.Synonyms: CHEK-2, CHEK2, CHK-2, CHK2 checkpoint homolog, Cds1, RAD53, Serine/threonine-protein kinase Chk2
ImmunogenRecombinant Chk2 protein. Remarks: Mol. Wt. of Antigen: ~70 kDa
Other NamesCHK-2|CDS1|CHK2|HuCds1|LFS2|PP1425|RAD53|hCds1|Cds1|HUCDS1|Rad53|Chk2|fa66f08|wu:fa66f08|zgc:55865
Gene, Accession #Gene ID: 11200
Catalog #ABIN180451
Price
Order / More InfoCheckpoint Kinase 2 (CHEK2) Antibody from ANTIBODIES-ONLINE GmbH
Product Specific Referencesn/a
产品资料