产品名称 Cell Division Cycle 34 Homolog (S. Cerevisiae) (CDC34) protein (His tag) from ANTIBODIES-ONLINE GmbH
产品货号 ABIN2745896
产品价格 现货询价,电话:010-67529703
产品规格 100 µg
产品品牌 ANTIBODIES-ONLINE GmbH
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Product NameCell Division Cycle 34 Homolog (S. Cerevisiae) (CDC34) protein (His tag)
DescriptionUbiquitin-conjugating Enzyme H3 (UbcH3), also known as Cell Division Cycle 34 (Cdc34), is a member of the ubiquitin-conjugating (E2) enzyme family. UbcH3 has a predicted molecular weight of 26 kDa. The human protein shares 98% amino acid (aa) sequence identity with the mouse and rat orthologs. In addition to an E2 catalytic core domain, UbcH3 has two ubiquitin binding sites, UBS1, from aa 205-215, and UBS2, from aa 216-225, and a C-terminal acidic tail domain. UbcH3 is required for efficient cell cycle progression in human cells. UbcH3 interacts with the SCF(Fbw7) and SCF(Skp2) ubiquitin ligases (E3s) to target the key cell cycle proteins Myc and p27/Kip1, respectively, for ubiquitination and degradation. Furthermore, CK2 has been shown to phosphorylate human UbcH3 on Ser203, Ser222, and Ser231 in cycling cells. The proliferation of cancer cell lines is inhibited following treatment with a human UbcH3 inhibitor, suggesting that UbcH3 also plays a significant role in cancer.
Size100 µg
Concentrationn/a
ApplicationsSDS-PAGE (SDS)
Other Namese2-cdc34|ubc3|ube2r1|CDC34|DNA6|UBC3|CDC34B|UBE2R2|E2-CDC34|UBCH3|UBE2R1|AI327276
Gene, Accession, CAS #Gene ID: 997
Catalog #ABIN2745896
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Order / More InfoCell Division Cycle 34 Homolog (S. Cerevisiae) (CDC34) protein (His tag) from ANTIBODIES-ONLINE GmbH
Product Specific Referencesn/a
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