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| Product Name | Cell Division Cycle 37 Homolog (S. Cerevisiae) (CDC37) protein |
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| Description | CDC37 is an essential protein in Saccharomyces cerevisiae and is a molecular chaperone with precise function in cell signal transduction. CDC37 forms a complex/associates with Hsp90 molecular chaperone as one of several auxiliary proteins that are collectively referred to as Hsp90 co-chaperones. CDC37 also forms complex with a number of protein kinases such as CDK4, CDK6, SRC, RAF-1, MOK, as well as eIF2 alpha kinases. CDC34 is involved in directing Hsp90 to its target kinases. CDC37 up-regulation is a common early event in some localized human cancers. CDC37 is necessary for maintaining prostate tumor cell growth and represents a novel target in the exploration for multitargeted therapies. CDC37 plays a role in regulating Hsp90 ATPase activity. CDC37 binds to Akt and HSP90 in the signal transduction pathway in human tumor cells. Tnf-induced recruitment and activation of the IKK complex require Cdc37 and Hsp90. CDC37 and heat shock protein 90 bind specifically to the kinase domain of LKB1 Synonyms: P50CDC37, CDC-37, CDC37, Hsp90 co-chaperone Cdc37, Hsp90 chaperone protein kinase-targeting subunit, CDC37A, Cell Division Cycle 37 |
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| Size | 1 mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | CG12019|CPDR-1|CPDR-2|DROCPDR|Dmel\\CG12019|E(sev)3B|cdc37|Afu4g10010|P50CDC37|p50|p50Cdc37 |
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| Gene, Accession, CAS # | Gene ID: 11140 |
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| Catalog # | ABIN807015 |
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| Order / More Info | Cell Division Cycle 37 Homolog (S. Cerevisiae) (CDC37) protein from ANTIBODIES-ONLINE GmbH |
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| Product Specific References | n/a |
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