| 产品详情 |
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| Product Name | AZD 3759 |
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| Description | A brain penetrant inhibitor of EGFR (IC50s = 0.3, 0.2, and 0.2 nM for wild-type, L858R-mutant, and exon 19 deletion-containing EGFRs, respectively); selective for EGFR over 115 other kinases, exhibiting 50s = 7.7 and 7.0 nM, respectively) but has no effect on H838 cells that express wild-type EGFR (GI50 = 21,556 nM); inhibits tumor growth by 78% and induces tumor regression at doses of 7.5 and 15 mg/kg, p.o., respectively in a PC-9 mouse model of NSCLC brain metastasis |
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| Size | 10 mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | AZD3759 CNS pEGFR PC9 H-3255 |
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| Gene, Accession, CAS # | CAS: 1626387-80-1 |
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| Catalog # | 19931-10 |
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| Price | |
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| Order / More Info | AZD 3759 from CAYMAN CHEMICAL COMPANY |
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| Product Specific References | n/a |
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