产品名称 Recombinant Human Serine/threonine-protein kinase N1 (PKN1), partial from BIOMATIK
产品货号 RPC25776
产品价格 现货询价,电话:010-67529703
产品规格 100ug
产品品牌 BIOMATIK
产品概述
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Product NameRecombinant Human Serine/threonine-protein kinase N1 (PKN1), partial
DescriptionPurity > 85% as determined by SDS-PAGE. MW: 34.5kDa. Partial: 190-467aa. N-terminal 6xHis-tagged. Homo sapiens (Human). PKC-related serine/threonine-protein kinase involved in various processes such as regulation of the intermediate filaments of the actin cytoskeleton, cell migration, tumor cell invasion and transcription regulation. Part of a signaling cascade that begins with the activation of the adrenergic receptor ADRA1B and leads to the activation of MAPK14. Regulates the cytoskeletal network by phosphorylating proteins such as VIM and neurofilament proteins NEFH, NEFL and NEFM, leading to inhibit their polymerization. Phosphorylates 'Ser-575', 'Ser-637' and 'Ser-669' of MAPT/Tau, lowering its ability to bind to microtubules, resulting in disruption of tubulin assembly. Acts as a key coactivator of androgen receptor-dependent transcription, by being recruited to ANDR target genes and specifically mediating phosphorylation of 'Thr-11' of histone H3, a specific tag for epigenetic transcriptional activation that promotes demethylation of histone H3 'Lys-9' by KDM4C/JMJD2C. Phosphorylates HDAC5, HDAC7 and HDAC9, leading to impair their import in the nucleus. Phosphorylates 'Thr-38' of PPP1R14A, 'Ser-159', 'Ser-163' and 'Ser-170' of MARCKS, and GFAP. Able to phosphorylate RPS6 in vitro.
Size100ug
Concentrationn/a
ApplicationsRUO
Other NamesProtease-activated kinase 1 (PAK-1) (Protein kinase C-like 1) (Protein kinase C-like PKN) (Protein kinase PKN-alpha) (Protein-kinase C-related kinase 1) (Serine-threonine protein kinase N ) (PAK1) (PKN) (PRK1) (PRKCL1)
Gene, Accession, CAS #PKN1, UniProt: Q16512
Catalog #RPC25776
Price
Order / More InfoRecombinant Human Serine/threonine-protein kinase N1 (PKN1), partial from BIOMATIK
Product Specific Referencesn/a
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