| 产品详情 |
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| Product Name | GN25 |
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| Description | MW: 322.3. Purity ≥98%. GN25 blocks Snail binding to p53 and induces p53 expression in cancer cells in a KRas dependent manner. Oncogenic KRas has been shown to inhibit p53 function by inducing Snail to bind and eliminate p53 through exocytosis. At 10 muM; GN25 significantly reduces cell proliferation in KRas mutated A549 and HCT116 cell lines but not in wild type MKN-45 cells. In a xenograft mouse model; 10 mg/kg GN25 yields antitumoral effects by notably reducing tumor size and progression. |
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| Size | 5 mg, 25 mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | [3-?[ (1; ?4-?dihydro-?5; ?8-?dimethoxy-?1; ?4-?dioxo-?2-?naphthalenyl)thio]-?propanoic acid] |
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| Gene, Accession, CAS # | CAS: 1227401-27-5 |
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| Catalog # | MBS845633 |
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| Price | |
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| Order / More Info | GN25 from MYBIOSOURCE INC. |
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| Product Specific References | n/a |
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| 产品资料 |
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