产品名称 C-Fos Antibody from ANTIBODIES-ONLINE GmbH
产品货号 ABIN1683601
产品价格 现货询价,电话:010-67529703
产品规格 50 µg
产品品牌 ANTIBODIES-ONLINE GmbH
产品概述
产品详情
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Antigenic SpecificityC-Fos
Clonepolyclonal
Host SpeciesRabbit
Reactive Speciesmouse, rat, human
Isotypen/a
Formataffinity purified
Size50 µg
Concentrationn/a
ApplicationsWestern Blotting (WB),Immunohistochemistry (IHC)
Reviews / RatingsIf you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY.
DescriptionThe Fos family of nuclear oncogenes includes c-Fos, FosB, Fos-related antigen 1 (FRA1), and Fos-related antigen 2 (FRA2) . While most Fos proteins exist as a single isoform, the FosB protein exists as two isoforms: full-length FosB and a shorter form, FosB2 (Delta FosB), that lacks the carboxy-terminal 101 amino acids . The expression of Fos proteins is rapidly and transiently induced by a variety of extracellular stimuli including growth factors, cytokines, neurotransmitters, polypeptide hormones, and stress. Fos proteins dimerize with Jun proteins (c-Jun, JunB, and JunD) to form Activator Protein-1 (AP-1), a transcription factor that binds to TRE/AP-1 elements and activates transcription. Fos and Jun proteins contain the leucine-zipper motif that mediates dimerization and an adjacent basic domain that binds to DNA. The various Fos/Jun heterodimers differ in their ability to transactivate AP-1 dependent genes. In addition to increased expression, phosphorylation of Fos proteins by Erk kinases in response to extracellular stimuli may further increase transcriptional activity . Phosphorylation of c-Fos at Ser32 and Thr232 by Erk5 increases protein stability and nuclear localization . Phosphorylation of FRA1 at Ser252 and Ser265 by Erk1/2 increases protein stability and leads to overexpression of FRA1 in cancer cells . Following growth factor stimulation, expression of FosB and c-Fos in quiescent fibroblasts is immediate, but very short-lived, with protein levels dissipating after several hours . FRA1 and FRA2 expression persists longer and appreciable levels can be detected in asynchronously growing cells . Deregulated expression of c-Fos, FosB, or FRA2 can result in neoplastic cellular transformation, however, Delta FosB lacks the ability to transform cells . Synonyms: FOS ,AP-1,C-FOS,Proto-oncogene c-Fos,
ImmunogenCenter-peptide of human FOS
Other NamesAP-1|C-FOS|p55|c-fos|D12Rfj1|cFos|cFOS|fos
Gene, Accession #Gene ID: 2353,14281,314322
Catalog #ABIN1683601
Price
Order / More InfoC-Fos Antibody from ANTIBODIES-ONLINE GmbH
Product Specific Referencesn/a
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