产品名称 Caveolin 1, Caveolae Protein, 22kDa (CAV1) Antibody from ANTIBODIES-ONLINE GmbH
产品货号 ABIN2192105
产品价格 现货询价,电话:010-67529703
产品规格 100 µg
产品品牌 ANTIBODIES-ONLINE GmbH
产品概述
产品详情
Edit&nbsp
Antigenic SpecificityCaveolin 1, Caveolae Protein, 22kDa (CAV1)
Clone7C8
Host SpeciesMouse
Reactive Speciesrat
Isotypen/a
Formatunconjugated
Size100 µg
Concentrationn/a
ApplicationsWestern Blotting (WB)
Reviews / RatingsIf you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY.
DescriptionThe monoclonal antibody 7C8 recognizes rat caveolin-1, a membrane protein of ~22 kDa. Caveolae are sphingomyelin/cholesterol-rich membrane domains first discovered as membrane invaginations on the surface of endothelial and epithelial cells. Caveolae are present in most cells, but are especially abundant in adipocytes. In addition to caveolins only two major protein components of caveolae were identified, namely the semicarbazide sensitive amine oxidase (SSAO) and the scavenger receptor CD36. Caveolin cycles between the plasma membrane and intracellular compartments via the endocytotic pathway. Caveolin is involved in the rapid intracellular transport of newly synthesized cholesterol from the ER directly to the caveolae. Caveolin plays an important role in multiple signaling pathways, molecular transport and cellular proliferation and differentiation. Caveolin binds to endothelial nitric oxide synthase leading to enzyme inhibition. Furthermore caveolin is a candidate tumor suppressor gene in many tumors. The specific functions of caveolin-1/caveolae are highly cell and context dependent. The monoclonal antibody 7C8 recognizes caveolin-1α as well as caveolin-1β, which are present in many tissues, like aorta, heart, muscle, lung, adipose white, brown and epidydimal fat. The monoclonal antibody 7C8 can be used to immuno-isolate caveolae. Immunogen GLUT4-containing vesicles immunoadsorbed from low density microsomes of rat adipocytes (Sprague Dawley) (Ref 4)
Immunogenn/a
Other Namesfc07c04|wu:fc07c04|Cav-1|bscl3|cav1|cav1a|cgl3|vip21|cav1b|caveolin-1|cav|mstp085|Caveolin-1|CAV1|cav-1|Cav|caveolin 1|BSCL3|CGL3|MSTP085|PPH3|VIP21
Gene, Accession #Gene ID: 25404
Catalog #ABIN2192105
Price
Order / More InfoCaveolin 1, Caveolae Protein, 22kDa (CAV1) Antibody from ANTIBODIES-ONLINE GmbH
Product Specific ReferencesPubMed: 12637562, 21152401, 8505298
产品资料