| 产品详情 |
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| Antigenic Specificity | ATG4C |
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| Clone | polyclonal |
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| Host Species | Rabbit |
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| Reactive Species | human, mouse |
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| Isotype | n/a |
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| Format | purified |
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| Size | 80 µl, 400 µl |
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| Concentration | n/a |
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| Applications | WB, IHC. RUO |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | Macroautophagy is the major inducible pathway for the general turnover of cytoplasmic constituents in eukaryotic cells, it is also responsible for the degradation of active cytoplasmic enzymes and organelles during nutrient starvation. Macroautophagy involves the formation of double-membrane bound autophagosomes which enclose the cytoplasmic constituent targeted for degradation in a membrane bound structure, which then fuse with the lysosome (or vacuole) releasing a single-membrane bound autophagic bodies which are then degraded within the lysosome (or vacuole). APG4 is a cysteine protease required for autophagy, which cleaves the C-terminal part of either MAP1LC3, GABARAPL2 or GABARAP, allowing the liberation of form I. A subpopulation of form I is subsequently converted to a smaller form (form II). Form II, with a revealed C-terminal glycine, is considered to be the phosphatidylethanolamine (PE) conjugated form, and has the capacity for the binding to autophagosomes. This ATG4C antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 419-448 amino acids from the C-terminal region of human ATG4C. |
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| Immunogen | Human ATG4C. |
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| Other Names | APG4 autophagy 4 homolog C; APG4-C; APG4C; AUT-like 3 cysteine endopeptidase; AUTL1; AUTL3; autophagin-3; autophagy-related cysteine endopeptidase; autophagy-related cysteine endopeptidase 3; autophagy-related protein 4 homolog C; cysteine protease ATG4C; AUT; ATG4C; ATG4 autophagy related 4 homolog C (S. cerevisiae); FLJ14867; AUT-like 1, cysteine endopeptidase; OTTHUMP00000010715; autophagy-related cystei |
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| Gene, Accession # | Accession: NP_116241.2, NP_835739.1, SwissProt: Q96DT6 |
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| Catalog # | abx030028 |
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| Price | |
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| Order / More Info | ATG4C Antibody from ABBEXA |
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| Product Specific References | n/a |
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