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| Product Name | WM852 Purified Genomic DNA |
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| Description | DNA was prepared from cell line WM852. WM852 is a metastaic melanoma cell line with epithelial morphology. This cell line was established from the metastatic site (abdomen) in a 63-year -old male. This cell line contains a Q61R mutation at position 61 in the N-RAS gene. The Q61R is the most common NRAS mutation found in melanoma that is thought to occur due to UV and radiation exposure. This mutation leads to production of a constitutively active N-RAS protein that directs cells to grow and divide constantly. This cell line also expresses PTEN loss of function including hemizygous deletion and is wild type for BRAF, c-KIT and CDK4. WM852 cells produce xenograft tumors when injected into immunocompromised mice. |
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| Size | 25 µg |
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| Concentration | 200 ng / µl |
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| Applications | Purified Genomic DNA is suitable for a number of molecular biology applications including but not limited to preparation of genomic libraries, PCR templates, DNA sequencing, DNA fingerprinting, and mutation analysis. |
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| Other Names | Human Melanoma, patient derived tumor, tumor models, skin cancer, xenograft |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | WM852-02-5000 |
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| Order / More Info | WM852 Purified Genomic DNA from ROCKLAND IMMUNOCHEMICALS INC. |
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| Product Specific References | Friedegund Meier et al. Human Melanoma Progression in Skin Reconstructs: Biological Significance of bFGF. Am J Pathol. (2000); 156(1): 193-200. doi: 10.1016/S0002-9440(10)64719-5 |
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