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| Product Name | WM266-4 Viable Cells (10 x 10^6 cells) |
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| Description | WM266-4 is a metastatic human melanoma cell line with small flat mesenchymal morphology. This cell line was derived from the same patient as the cell lines WM115, WM293A, and WM165-1. WM115 cell line originated from the primary tumor, and WM266-4, WM165-1 and WM293A were from individual lymph-node metastases. The subject (55-year-old female) displayed VGP with a Clark level III tumor with thickness of 2.24mm.This cell line features the specific V600D (Val600Asp) mutation at codon 600 in the BRAF gene. This cell line also expresses PTEN loss of function including hemizygous deletion. WM266-4 cell line is wild type for N-RAS, c-KIT, and CDK4 genes. WM266-4 cells produce xenograft tumors when injected into immunocompromised mice. |
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| Size | 1 mL |
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| Concentration | 10.0 million cells/ml |
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| Applications | The key applications of these cell lines include genetic studies, xenograft production, drug testing, and drug target discovery. These cell line models can be used in various biological assays, and for identifying critical target genes, and cell signaling pathways. |
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| Other Names | Human Melanoma, patient derived tumor, tumor models, skin cancer, xenograft |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | WM266-4-01-0010 |
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| Order / More Info | WM266-4 Viable Cells (10 x 10^6 cells) from ROCKLAND IMMUNOCHEMICALS INC. |
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| Product Specific References | n/a |
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