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| Product Name | WM2044 Viable Cells (1 x10^6 cells) |
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| Description | WM2044 is a metastatic human melanoma cell line that displays mesenchymal morphology. These cells require insulin for growth in culture. This cell line features the specific V600E (Val600Glu) mutation at codon 600 in the BRAF gene. This mutation causes constitutively active kinase activity and activation of MEK and ERK signaling pathway. This cell line also expresses PTEN loss of function including hemizygous deletion, and is wild type for N-RAS, c-KIT, and CDK4. WM2044 cells produce xenograft tumors when injected into immunocompromised mice. |
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| Size | 1 mL |
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| Concentration | 1.0 million cells/ml |
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| Applications | The key applications of these cell lines include genetic studies, xenograft production, drug testing, and drug target discovery. These cell line models can be used in various biological assays, and for identifying critical target genes, and cell signaling pathways. |
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| Other Names | Human Melanoma, patient derived tumor, tumor models, skin cancer, xenograft |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | WM2044-01-0001 |
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| Order / More Info | WM2044 Viable Cells (1 x10^6 cells) from ROCKLAND IMMUNOCHEMICALS INC. |
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| Product Specific References | n/a |
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