| 产品详情 |
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| Antigenic Specificity | GRK2, C-Terminus |
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| Clone | polyclonal |
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| Host Species | Goat |
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| Reactive Species | human, mouse |
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| Isotype | n/a |
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| Format | immunoaffinity purified |
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| Size | 100 µg |
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| Concentration | 1.0 mg/ml |
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| Applications | ELISA, Immunohistochemistry, Western Blot. Anti-GRK2 Antibody has been tested in ELISA, Western Blot, and IHC. Expect a band at ~79.6kDa in western blot using appropriate lysates. Positive control used: Human high grade lymphoma tissue in Immunohistochemistry and THP-1 lysate in western blot. |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | This affinity purified antibody is directed against human GRK2. This product was affinity purified from monospecific antiserum by immunoaffinity purification. A BLAST analysis of the sequence shows 100% reactivity to human, and 90% to rat, mouse, and golden hamster. . GRK2 (G Protein-Coupled Receptor Kinase 2) is a member of the G protein-coupled receptor kinase family of proteins. GRK2 Specifically phosphorylates the agonist-occupied form of the beta-adrenergic and as well as a wide range of other substrates including non-GPCR cell surface receptors, and cytoskeletal, mitochondrial, and transcription factor proteins. It is a key regulator of LPAR1 signaling. GRK2 competes with RALA for binding to LPAR1 thus affecting the signaling properties of the receptor. It desensitizes LPAR1 and LPAR2 in a phosphorylation-independent manner. And positively regulates ciliary smoothened (SMO)-dependent Hedgehog (Hh) signaling pathway by facilitating the trafficking of SMO into the cilium and the stimulation of SMO activity. Data from rodent models supports a role for this gene in embryonic development, heart function and metabolism. Elevated expression of this gene has been observed in human patients with heart failure and Alzheimer's disease. Anti-GRK2 Antibody is useful for researchers interested in Neuroscience, Cytokines & Growth Factors, and Stem Cell Research. |
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| Immunogen | Anti-GRK2 antibody was prepared from whole goat serum produced by repeated immunizations with a synthetic peptide corresponding to a near C-terminal portion of human GRK2 conjugated to Keyhole Limpet Hemocyanin (KLH). |
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| Other Names | Goat Anti-G Protein-Coupled Receptor Kinase 2 Antibody, Goat Anti-GRK2 Antibody, Beta-ARK-1, ADRBK1, BARK1, G-Protein Coupled Receptor Kinase 2, Adrenergic, Beta, Receptor Kinase 1, Adrenergic Beta Receptor Kinase 1, Beta-Adrenergic Receptor Kinase 1, EC 2.7.11.15, BETA-ARK1, BARK |
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| Gene, Accession # | GRK2, Gene ID: 156, UniProt: P25098, NCBI: NP 001610.2 |
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| Catalog # | 600-101-MH5 |
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| Price | |
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| Order / More Info | GRK2, C-Terminus Antibody from ROCKLAND IMMUNOCHEMICALS INC. |
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| Product Specific References | n/a |
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