产品名称 Interleukin 17A (IL17A) protein from ANTIBODIES-ONLINE GmbH
产品货号 ABIN1540530
产品价格 现货询价,电话:010-67529703
产品规格 5 µg
产品品牌 ANTIBODIES-ONLINE GmbH
产品概述
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Product NameInterleukin 17A (IL17A) protein
DescriptionInterleukin 17 (also known as CTLA-8) is a T cell-expressed pleiotropic cytokine that exhibits a high degree of homology to a protein encoded by the ORF13 gene of herpesvirus Saimiri. cDNA clones encoding IL-17 have been isolated from activated rat, mouse and human T cells. Human IL-17 cDNA encodes a 155 amino acid (aa) residue precursor protein with a 19 amino acid residue signal peptide that is cleaved to yield the 136 aa residue mature IL-17 containing one potential N-linked glycosylation site. Both recombinant and natural IL-17 have been shown to exist as disulfide linked homodimers. At the amino acid level, human IL-17 shows 72% and 63% sequence identity with herpesvirus and rat IL-17, respectively. An IL-17 specific mouse cell surface receptor (IL-17 R) has recently been cloned. While the expression of IL-17 mRNA is restricted to activated T cells, the expression of mIL-17 R mRNA has been detected in virtually all cells and tissues tested. IL-17 exhibits multiple biological activities on a variety of cells including the induction of IL-6 and IL-8 production in fibroblasts, the enhancement of surface expression of ICAM-1 in fibroblasts, activation of NF-kappaB and costimulation of T cell proliferation.
Size5 µg
Concentrationn/a
Applicationsn/a
Other NamesIl17|IL17A|CTLA8|IL-17|IL-17A|IL17|Ctla-8|Ctla8|CTLA-8|ChIL-17|IL-17F
Gene, Accession, CAS #Gene ID: 100034142, 449530
Catalog #ABIN1540530
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Order / More InfoInterleukin 17A (IL17A) protein from ANTIBODIES-ONLINE GmbH
Product Specific Referencesn/a
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