产品名称 NF-kB p50 (Active) protein (His tag) from ANTIBODIES-ONLINE GmbH
产品货号 ABIN2745766
产品价格 现货询价,电话:010-67529703
产品规格 2 µg
产品品牌 ANTIBODIES-ONLINE GmbH
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Product NameNF-kB p50 (Active) protein (His tag)
DescriptionNF-kappaB is a pleiotropic transcription factor present in almost all cell types and is the endpoint of a series of signal transduction events that are initiated by a vast array of stimuli related to many biological processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappaB is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52. The heterodimeric p65-p50 complex is the most abundant complex. The dimers bind at kappaB sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappaB sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. NF-kappaB complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappaB inhibitor (I-kappaB) family. In a conventional activation pathway, I-kappaB is phosphorylated by I-kappaB kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappaB complex which translocates to the nucleus. NF-kappaB heterodimeric p65-p50 and RelB-p50 complexes are transcriptional activators. The NF-kappaB p50-p50 homodimer is a transcriptional repressor, but can act as a transcriptional activator when associated with BCL3.
Size2 µg
Concentrationn/a
ApplicationsSDS-PAGE (SDS)
Other Namesn/a
Gene, Accession, CAS #n/a
Catalog #ABIN2745766
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Order / More InfoNF-kB p50 (Active) protein (His tag) from ANTIBODIES-ONLINE GmbH
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