产品名称 Factor VIIa protein from ANTIBODIES-ONLINE GmbH
产品货号 ABIN806778
产品价格 现货询价,电话:010-67529703
产品规格 1 mg
产品品牌 ANTIBODIES-ONLINE GmbH
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Product NameFactor VIIa protein
DescriptionCoagulation factor VII is a vitamin K-dependent factor which is essential for hemostasis. It circulates in the blood as a zymogen which is later converted to an active form by factor IXa, factor Xa, factor XIIa, or thrombin by minor proteolysis. Upon activation of factor VII, a heavy chain with a catalytic domain and a light chain with 2 EGF-like domains are generated, and the two chains are held together by a disulfide bond. The presence of factor III and calcium ions further activates the coagulation cascade by converting factor IX to factor IXa and/or factor X to factor Xa. Alternative splicing of factor VII results in 2 transcripts. Defects in coagulation factor VII can cause coagulopathy. Coagulation factor VII initiates the extrinsic pathway of blood coagulation. Minor proteolysis converts factor VII to factor VIIa by factors Xa, XIIa, IXa, or thrombin. Factor VIIa also converts factor IX to factor IXa in the presence of tissue factor and calcium Synonyms: Coagulation factor VII, EC 3.4.21.21, Serum prothrombin conversion accelerator, SPCA, Proconvertin, Eptacog alfa, F7.
Size1 mg
Concentrationn/a
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Catalog #ABIN806778
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Order / More InfoFactor VIIa protein from ANTIBODIES-ONLINE GmbH
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