| 产品详情 |
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| Antigenic Specificity | TREM1 |
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| Clone | polyclonal |
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| Host Species | Rabbit |
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| Reactive Species | mouse |
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| Isotype | n/a |
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| Format | immunogen affinity purified |
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| Size | 100ug (sample available) |
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| Concentration | 500ug/ml. |
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| Applications | IHC, WB |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | Rabbit IgG polyclonal antibody for Triggering receptor expressed on myeloid cells 1(TREM1) detection. Tested with WB, IHC-P in Mouse. No cross reactivity with other proteins. Trem1, Triggering receptor expressed on myeloid cells-1, is encoded by Trem1 gene. The expression of Trem1 is in monocytes and neutrophils but not in lymphocytes, dendritic cells, or other cell types. Trem1 is a 30-kD glycoprotein that is reduced to 26 kD by deglycosylation, in agreement with the predicted molecular mass. The Trem1 gene which contains 4 exons maps to chromosome 6p21.1, within a TREM gene cluster and the mouse Trem1 gene maps to chromosome 17 in a region that shows homology of synteny to human chromosome 6. The expression of Trem1 is upregulated by stimulation with lipopolysaccharide(LPS), gram-negative bacteria, and fungi. Cross-linking of Trem1 on neutrophils induces interleukin-8(IL8) and myeloperoxidase secretion, while cross-linking on monocytes induces not only secretion of IL8 but also of monocyte chemotactic protein-1(MCP1, or SCYA2) and tumor necrosis factor(TNF); MCP1 and TNF secretion could be further upregulated by LPS-mediated priming. Trem1 engagement also induces upregulation of adhesion molecules(e.g., ITGB1) and costimulatory molecules(e.g., CD40). Trem1 is associated with DAP12(TYROBP), a molecule frequently associated with activating receptors. |
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| Immunogen | A synthetic peptide corresponding to a sequence in the middle of mouse TREM1(74-90aa FTRPSEVHMGKFTLKHD). |
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| Other Names | Triggering receptor expressed on myeloid cells 1;TREM-1;CD354;Trem1; |
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| Gene, Accession # | TREM1, UniProt: Q9JKE2 |
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| Catalog # | PA1586 |
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| Price | |
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| Order / More Info | TREM1 Antibody from BOSTER BIO |
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| Product Specific References | n/a |
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