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| Product Name | B and T Lymphocyte Associated (BTLA) (C-Term) protein |
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| Description | Recombinant Human B-andT-lymphocyte attenuator/BTLA/CD272 is produced by our mammalian expression system. The target protein is expressed with sequence (Lys31-Leu150) of Human BTLA fused with FC and polyhistidine tag at the C-terminus. B- and T-Lymphocyte Attenuator (BTLA) is a single-pass type I membrane protein containing 1 Ig-like V-type (immunoglobulin-like) domain. BTLA expression is induced during activation of T cells, and BTLA remains expressed on Th1 cells but not Th2 cells. Like PD1 and CTLA4, BTLA interacts with a B7 homolog, B7H4. However, unlike PD-1 and CTLA-4, BTLA displays T-Cell inhibition via interaction with tumor necrosis family receptors (TNF-R), not just the B7 family of cell surface receptors. BTLA is a lymphocyte inhibitory receptor that inhibits lymphocytes during immune response. BTLA also is a ligand for tumor necrosis factor (receptor) superfamily, member 14 (TNFRSF14), also known as herpes virus entry mediator (HVEM). BTLA-HVEM complexes negatively regulate T-cell immune responses. |
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| Size | 50 µg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | BTLA|BTLA1|CD272|A630002H24 |
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| Gene, Accession, CAS # | Gene ID: 151888 |
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| Catalog # | ABIN1691506 |
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| Order / More Info | B and T Lymphocyte Associated (BTLA) (C-Term) protein from ANTIBODIES-ONLINE GmbH |
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| Product Specific References | n/a |
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