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| Antigenic Specificity | Programmed Cell Death 4 (Neoplastic Transformation Inhibitor) (PDCD4) (pSer457) |
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| Clone | 2E10-C12 |
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| Host Species | Mouse |
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| Reactive Species | human, mouse, rat, Xenopus laevis |
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| Isotype | IgG1 kappa |
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| Format | unconjugated |
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| Size | 1 mg |
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| Concentration | n/a |
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| Applications | Western Blotting (WB),ELISA,Immunohistochemistry (IHC) |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | Programmed cell death 4 (Pdcd4) is a novel tumor supressor. Pdcd4 directly inhibits the helicase activity of eukaryotic translation initiation factor 4A (eIF4A), a component of the translation initiation complex. Pdcd4 also suppresses the transactivation of activator protein-1 (AP-1)-responsive promoters by c-Jun. Pdcd4 contains two Akt phosphoryl-ation sites, one at Ser67 and the other at Ser457. The phosphorylation of Pdcd4 by Akt causes nuclear translocation of Pdcd4 and a significant decrease in the ability of Pdcd4 to interfere with the transactivation of AP-1-responsive promoters by c-Jun. Ideal for researchers involved in Cell Signaling, Cancer and Signal Transduction research.Synonyms: Death up-regulated gene protein antibody, Dug antibody, H731 antibody, Ma3 antibody, Neoplastic transformation inhibitor antibody, Neoplastic transformation inhibitor protein antibody, Nuclear antigen H731 antibody |
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| Immunogen | Anti-Pdcd4 phospho S457 Antibody was produced by repeated immunizations with a synthetic peptide corresponding to residues surrounding Ser457 of the human Pdcd4 protein.Immunogen Type: Peptide |
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| Other Names | h731|MGC69337|PDCD4|D19Ucla1|Ma3|Tis|Dug|H731 |
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| Gene, Accession # | Gene ID: 380222,27250,18569,64031 |
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| Catalog # | ABIN1043728 |
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| Order / More Info | Programmed Cell Death 4 (Neoplastic Transformation Inhibitor) (PDCD4) (pSer457) Antibody from ANTIBODIES-ONLINE GmbH |
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| Product Specific References | PubMed: 16024603, 19419954 |
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