产品名称 SHC (Src Homology 2 Domain Containing) Transforming Protein 1 (SHC1) peptide from ANTIBODIES-ONLINE GmbH
产品货号 ABIN936531
产品价格 现货询价,电话:010-67529703
产品规格 100 µg
产品品牌 ANTIBODIES-ONLINE GmbH
产品概述
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Product NameSHC (Src Homology 2 Domain Containing) Transforming Protein 1 (SHC1) peptide
DescriptionSHC1 is a signaling adapter that couples activated growth factor receptors to signaling pathway. Isoform p46Shc and isoform p52Shc, once phosphorylated, couple activated receptor tyrosine kinases to Ras via the recruitment of the GRB2/SOS complex and are implicated in the cytoplasmic propagation of mitogenic signals. Isoform p46Shc and isoform p52Shc may thus function as initiators of the Ras signaling cascade in various non-neuronal systems. Isoform p66Shc does not mediate Ras activation, but is involved in signal transduction pathways that regulate the cellular response to oxidative stress and life span. Isoform p66Shc acts as a downstream target of the tumor suppressor p53 and is indispensable for the ability of stress-activated p53 to induce elevation of intracellular oxidants, cytochrome c release and apoptosis.
Size100 µg
Concentrationn/a
ApplicationsWestern Blotting (WB),Immunohistochemistry (IHC),Blocking Peptide (BP)
Other NamesSHC1|SHC|SHCA|P66shc|si:dkey-246i14.4|wu:fc10h03|shc|p66shc|Shc|ShcA|p66
Gene, Accession, CAS #n/a
Catalog #ABIN936531
Price
Order / More InfoSHC (Src Homology 2 Domain Containing) Transforming Protein 1 (SHC1) peptide from ANTIBODIES-ONLINE GmbH
Product Specific Referencesn/a
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